The adrenal gland, located adjacent to the kidney, secretes hormones affecting metabolism and which also have general anti-inflammatory properties. The adrenal gland, produces cortisol in response to stimulation by the pituitary producing corticotropin. Excess thyroid corticotropin and resultant excess adrenal cortisol results in Cushing's Disease, previously mentioned. This age-related disease is common in Poodles, Boxers, Boston Terriers with mean age of onset of 8.5 years with symptoms of weakness, wrinkled skin, hair loss and hypertension. There is a well noted resemblance between normal aging symptoms and those of Cushing's Disease.

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