If the "King of Glands" is the hypothalmus, the Queen of Glands is the pituitary, then the Knave must be the thyroid gland. The thyroid gland controls metabolism, and makes glucose and fats available for energy. We would liken the thyroid gland to the chip that sets "clock speed" in a computer. Every system functions in cadence with that clock. Hypothyroidism (thyroid insufficiency) is common in purebred dogs, and especially as dogs age even if they never develop acute thyroiditis. The results are muscle wasting, lethargy, arthritis, and liver malfunction.

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